How to Build a Differential Diagnosis

Step by step

1. Summarize key findings.

2. List likely causes.

3. Add dangerous causes to rule out.

4. Order tests to narrow the list.

5. Reassess with results.

6. Update the plan.

Safety reminders for internists

• Reconcile medications
• Follow infection control
• Use structured handoffs
• Prevent falls and blood clots in hospital

Key terms

Hospitalist · Internal medicine · Differential diagnosis · Comorbidity · Polypharmacy · Rounds: see the full internist glossary.

More internist how-to guides

• How to lead a goals-of-care conversation
• How to write a discharge plan that prevents readmission